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Richter transformation stays an ominous function for sufferers with CLL, notably when it truly is clonally connected with the initial CLL, because none of the a short while ago authorized novel agents is really efficient. Indeed, condition transformation is a comparatively frequent cause of failure to benefit from these medicines.ninety,128,129 Histological affirmation is usually encouraged because it can information prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have extra favorable prognosis).
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Are BTK and PLCG2 mutations important and sufficient for ibrutinib resistance in Serious lymphocytic leukemia?
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